How to play a disc brake

We consider a gyroscopic system under the action of small dissipative and non-conservative positional forces, which has its origin in the models of rotating bodies of revolution being in frictional contact. The spectrum of the unperturbed gyroscopic system forms a "spectral mesh" in the plane "frequency -gyroscopic parameter" with double semi-simple purely imaginary eigenvalues at zero value of the gyroscopic parameter. It is shown that dissipative forces lead to the splitting of the semi-simple eigenvalue with the creation of the so-called "bubble of instability" - a ring in the three-dimensional space of the gyroscopic parameter and real and imaginary parts of eigenvalues, which corresponds to complex eigenvalues. In case of full dissipation with a positive-definite damping matrix the eigenvalues of the ring have negative real parts making the bubble a latent source of instability because it can "emerge" to the region of eigenvalues with positive real parts due to action of both indefinite damping and non-conservative positional forces. In the paper, the instability mechanism is analytically described with the use of the perturbation theory of multiple eigenvalues. As an example stability of a rotating circular string constrained by a stationary load system is studied in detail. The theory developed seems to give a first clear explanation of the mechanism of self-excited vibrations in the rotating structures in frictional contact, that is responsible for such well-known phenomena of acoustics of friction as the squealing disc brake and the singing wine glass.Comment: 25 pages, 9 figures, Presented at BIRS 07w5068 Workshop "Geometric Mechanics: Continuous and discrete, finite and infinite dimensional", August 12-17, 2007, Banff, Canad

secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila

Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion

Cosmological constraints from CMB distortion

We examine bounds on adiabatic and isocurvature density fluctuations from $\mu$-type spectral distortions of the cosmic microwave background (CMB). Studies of such distortion are complementary to CMB measurements of the spectral index and its running, and will help to constrain these parameters on significantly smaller scales. We show that a detection on the order of $\mu \sim 10^{-7}$ would strongly be at odds with the standard cosmological model of a nearly scale-invariant spectrum of adiabatic perturbations. Further, we find that given the current CMB constraints on the isocurvature mode amplitude, a nearly scale-invariant isocurvature mode (common in many curvaton models) cannot produce significant $\mu$-distortion. Finally, we show that future experiments will strongly constrain the amplitude of the isocurvature modes with a highly blue spectrum as predicted by certain axion models.Comment: 6 pages, 4 figures, version 3 contains a new figure showing the contribution to \mu_k as a function of k, and a clarification regarding the acoustic wave energy, accompanied by a related acknowledgement and referenc

Magnetic Helicity in Sphaleron Debris

We develop an analytical technique to evaluate the magnetic helicity in the debris from sphaleron decay. We show that baryon number production leads to left-handed magnetic fields, and that the magnetic helicity is conserved at late times. Our analysis explicitly demonstrates the connection between sphaleron-mediated cosmic baryogenesis and cosmic magnetogenesis.Comment: 9 pages, 1 figure. v2: Minor revisions; matches published version in Physical Review

Cosmological frames for theories with absolute parallelism

The vierbein (tetrad) fields for closed and open Friedmann-Robertson-Walker cosmologies are hard to work out in most of the theories featuring absolute parallelism. The difficulty is traced in the fact that these theories are not invariant under local Lorentz transformations of the vierbein. We illustrate this issue in the framework of f(T) theories and Born-Infeld determinantal gravity. In particular, we show that the early Universe as described by the Born-Infeld scheme is singularity free and naturally inflationary as a consequence of the very nature of Born-Infeld gravitational action.Comment: 8 pages, 1 figure. Talk given at the 8th Alexander Friedmann International Seminar on Gravitation and Cosmology, Rio de Janeiro, Brazil, June 2011. Submitted to the Proceeding

Exaggerated Risk: Prospect Theory and Probability Weighting in Risky Choice

In 5 experiments, we studied precautionary decisions in which participants decided whether or not to buy insurance with specified cost against an undesirable event with specified probability and cost. We compared the risks taken for precautionary decisions with those taken for equivalent monetary gambles. Fitting these data to Tversky and Kahneman’s (1992) prospect theory, we found that the weighting function required to model precautionary decisions differed from that required for monetary gambles. This result indicates a failure of the descriptive invariance axiom of expected utility theory. For precautionary decisions, people overweighted small, medium-sized, and moderately large probabilities—they exaggerated risks. This effect is not anticipated by prospect theory or experience-based decision research (Hertwig, Barron, Weber, & Erev, 2004). We found evidence that exaggerated risk is caused by the accessibility of events in memory: The weighting function varies as a function of the accessibility of events. This suggests that people’s experiences of events leak into decisions even when risk information is explicitly provided. Our findings highlight a need to investigate how variation in decision content produces variation in preferences for risk

Significance of arming, potentiating and blocking factors as correlates the tumour-host interaction in the hamster SV40 system.

The study of blocking factors requires in vitro assay of cell mediated immunity that parallels the in vivo response. By microcytotoxicity testing, progressor and immune peripheral blood lymphocytes caused significant target cell reduction. The cytotoxicity was specific as no cytotoxic effect was detected against unrelated normal as well as a malignant target cell lines. No anti-tumour effect was noted when progressor peripheral blood lymphocytes were evaluated in the Winn assay. In marked contrast, immune peripheral blood lymphocytes were capable of preventing tumour growth in the Winn assay. Furthermore, hamsters repeatedly immunized with irradiated SV40 tumour cells could resist a live cell challenge. Thus immune peripheral blood lymphocytes were chosen as the effector population to evaluate the abrogation ability of serum in the microcytotoxicity assay

Abnormal peri-operative haemorrhage in asymptomatic patients is not predicted by laboratory testing

The pre-operative identification of individuals at high risk of bleeding during tnajor elective surgery is obviously itnportant. Extensive haemostatic screening is, however, expensive and tnay be inappropriate in low-risk groups. Accordingly, we undertook two studies to detertnine whether it could be justified in patients without a history of abnormal bleeding. In the first of these, 45 of 159 patients were excluded because of aspirin ingestion and a further 3 because of positive bleeding history so that prothrombin time, activated partial thromboplastin time, bleeding time and platelet count were tneasured in 111 asytnptotnatic patients about to undergomajor surgery. A single patient had tnild thrombocytopenia, and 8 had a prolonged partial thromboplastin time; none showed abnormal peri-operative haemorrhage. In the second study, over a 4-month period, 49 patients out of 1 872 required larger peri-operative blood transfusions than anticipated; on investigation, none of these patients was shown to have disturbances in haemostatic mechanism, the transfusion having been indicated for technical reasons. Patients undergoing elective surgery should be asked about medication and previous bleeding and if they have no history thereof and a physical examination is negative, pre-operative screening for coagulation defects would appear to be unnecessary